The overall objective from this EFSA project is the compilation of a database specific for pesticide active substances and their metabolites, which is comprising the different genotoxicity endpoints i.e. point mutations, structural and numerical chromosome aberrations. The database represents a practical tool to complement the in-silico tools i.e. QSAR, grouping and read across for prediction and indication of the genotoxicity hazard.
The availability of a database specific for pesticides active substances and their metabolites is expected to increase the specificity and sensitivity of the in-silico tools and to enlarge the chemical domains for their applicability. The database includes information on the endpoints evaluated, the test system used, activity following metabolic activation and the underlying mechanism of genotoxicity.
This information is necessary to derive the residue definition for the dietary risk assessment, a key step in the evaluation of the dietary risk for consumers of food commodities containing pesticides residues.
One of the key recommendations for further work includes the creation of a web portal to improve the accessibility of the data.
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