{"id":2275,"date":"2017-05-31T10:00:57","date_gmt":"2017-05-31T10:00:57","guid":{"rendered":"https:\/\/lynxee.consulting\/?p=2275\/"},"modified":"2017-06-02T10:03:03","modified_gmt":"2017-06-02T10:03:03","slug":"europe-a-new-database-with-genotoxicity-endpoints","status":"publish","type":"post","link":"https:\/\/lynxee.consulting\/en\/europe-a-new-database-with-genotoxicity-endpoints\/","title":{"rendered":"EUROPE: A new database with genotoxicity endpoints"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">The overall objective from this EFSA project is the compilation of a database specific for pesticide active substances and their metabolites, which is comprising the different genotoxicity endpoints <\/span><i><span style=\"font-weight: 400;\">i.e.<\/span><\/i><span style=\"font-weight: 400;\"> point mutations, structural and numerical chromosome aberrations. The database represents a practical tool to complement the <\/span><i><span style=\"font-weight: 400;\">in-silico<\/span><\/i><span style=\"font-weight: 400;\"> tools<\/span><i><span style=\"font-weight: 400;\"> i.e.<\/span><\/i><span style=\"font-weight: 400;\"> QSAR, grouping and read across for prediction and indication of the genotoxicity hazard.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The availability of a database specific for pesticides active substances and their metabolites is expected to increase the specificity and sensitivity of the <\/span><i><span style=\"font-weight: 400;\">in-silico<\/span><\/i><span style=\"font-weight: 400;\"> tools and to enlarge the chemical domains for their applicability. The database includes information on the endpoints evaluated, the test system used, activity following metabolic activation and the underlying mechanism of genotoxicity. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">This information is necessary to derive the residue definition for the dietary risk assessment, a key step in the evaluation of the dietary risk for consumers of food commodities containing pesticides residues.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One of the key recommendations for further work includes the creation of a web portal to improve the accessibility of the data.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><b>To download: \u00a0<\/b><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.2903\/sp.efsa.2017.EN-1229\/pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Compilation of a database, specific for the pesticide active substance and their metabolites, comprising the main genotoxicity endpoints<\/span><\/a><\/p>\n<p>&nbsp;<\/p>\n<p><b>Lynxee consulting<\/b><span style=\"font-weight: 400;\">\u2019s team is at your disposal to answer your questions.<\/span><\/p>\n<p><b>Contact us!<\/b> <a href=\"https:\/\/lynxee.consulting\/en\/contact\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">https:\/\/lynxee.consulting\/en\/contact\/<\/span><\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The overall objective from this EFSA project is the compilation of a database specific for pesticide active substances and their metabolites, which is comprising the different<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":4,"featured_media":2274,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36],"tags":[218,163],"class_list":["post-2275","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-regulation","tag-genotoxicity","tag-residues"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.1.1 - 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